Pik3ca gene expression. Learn about this gene and related health conditions.

Pik3ca gene expression. Diseases associated with PIK3CA include Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome and Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi. PIK3CA is a gene that helps regulate cell growth. PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) is a gene that encodes the protein phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, a subunit of the PI3K protein. This review aimed to investigate publications and explore therapeutic approaches for PIK3CA-mutant breast cancer. Mutations can drive cancer and guide options for targeted therapy. These findings suggest that PIK3CA mutations contribute to cell proliferation, apoptosis suppression, and tumorigenesis through the activation of the PI3K/AKT/mTOR pathway. The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). It contributes PIK3CA mutations are involved in various type of cancer. PIK3CA is a gene that encodes one piece (a subunit) of an enzyme called phosphatidylinositol 3-kinase. The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO -approved official symbol = PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit. Mar 22, 2021 · One type of gene mutation that’s known to affect people with breast cancer is called PIK3CA. Jul 17, 2025 · PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha) is a Protein Coding gene. . PIK3CA plays a role in the way cell growth, cell survival, and cell migration are controlled. Learn about this gene and related health conditions. A mutation in the PIK3CA gene can cause cells to divide and replicate uncontrollably. Mar 3, 2025 · The PIK3CA gene provides instructions for making the protein known as p110α, and variants in this gene result in an overactive PI3K enzyme. With this increase in activity, affected cells grow and divide more than they should, leading to abnormal bone, soft tissue and blood vessel growth. Most of the cancer-associated mutations are missense mutations and map to one of the three hotspots: Glu-542; Glu-545 and His-1047. Mutated isoforms participate in cellular transformation and tumorigenesis induced by oncogenic receptor tyrosine kinases (RTKs) and HRAS/KRAS. mx6uc htp 0ookv0g qroe 4iob a3k46tu mtmib jtc wg60 25pw