Vulnerable plaque definition. The fourth section is .

Vulnerable plaque definition. It is divided into 4 sections. Feb 26, 2025 · Thin-cap fibroatheroma, a plaque with a large lipidic core covered by a thin fibrous cap, is the prototype of the rupture-prone plaque and has been traditionally defined as “vulnerable plaque. So-called vulnerable plaques are identified as nonobstructive and silent coronary lesions that suddenly turn obstructive and symptomatic [44]. Inflammation leads to the development of "soft" or vulnerable plaque. AI generated definition based on: Seminars in Nuclear Medicine, 2016 Aug 8, 2025 · Vulnerable or high-risk plaque (HRP) refers to coronary artery atherosclerotic lesions with features associated with future acute coronary events, independent of luminal stenosis. Many people who have heart attacks do not have arteries severely narrowed by plaque. This definition explained why certain plaques under certain stresses formed a thrombus and led to myocardial infarction (MI). . A vulnerable plaque is a kind of atheromatous plaque – a collection of white blood cells (primarily macrophages) and lipids (including cholesterol) in the wall of an artery – that is particularly unstable and prone to produce sudden major problems such as a heart attack or stroke. Since the first historical description of plaque rupture in 1844, several key studies by leading researchers and clinicians have lead to the current accepted Atherosclerosis continues to account for significant morbidity and mortality in most of the world. ” Given that advances in technology allow for imaging, access, and localized treatment of atherosclerotic plaques, enormous efforts have been devoted to recognizing “vulnerable plaques,” defined as rupture‐prone (or, more teleologically relevant, event‐prone) plaques and, subsequently, treating them. Oct 15, 2023 · In 1989, Muller et al 1 introduced the vulnerable plaque (VP) concept as a plaque prone to disruption and thrombosis. The major proportion of atherosclerosis mortality is related to atherosclerotic coronary artery disease, yet there still is not an optimal method for making the diagnosis of vulnerable plaque in vivo. The first section is devoted to definition, incidence, anatomic distribution, and clinical presentation. In fact, vulnerable plaque may be buried inside the artery wall and may not always bulge out and block the blood flow through the artery. The second section is devoted to plaque composition, setting up the foundations to understand plaque vulnerability. 1. The second section is devoted to plaque composition, setting up the foundations to understand pla … Vulnerable plaque is defined as a lipid-rich atherosclerotic plaque characterized by a thin fibrous cap and inflammatory infiltrates, often associated with macrophage activity, which can lead to cardiac events. The third section relates to invasive plaque imaging. The search for such an undefined method, along with studies on amelioration of currently This article provides a systematic approach to vulnerable plaques. The combination of a fibrous cap and a large lipid core is known as thin cap fibroatheroma (TCFA), a hallmark of vulnerable plaque [14, 28]. The fourth section is An atheromatous plaque in an arterial wall, which has abundant macrophages, gobs of lipids and cholesterol, and is usually covered by a thin fibrous cap which may rupture. Clinical presentation The relevant clinical sequelae of vulnerabl Jul 1, 2010 · Today’s concept of vulnerable plaque has evolved primarily from the early pioneering work uncovering the pivotal role of plaque rupture and coronary thrombosis as the major cause of acute myocardial infarction and sudden cardiac death. This article provides a systematic approach to vulnerable plaques. 4 The vulnerable plaque is defined as a nonobstructive, silent coronary lesion that suddenly becomes obstructive and symptomatic, as shown in Fig. 4ziljeq pcu aikom3 q6 tho1ir tucq kvjq x9f xs gjvj